The San Francisco 49ers are set to showcase their starters in their second preseason game, but several defensive players will be under close observation as they compete for roster spots and starting positions.
Alfred Collins, who struggled in his 2026 debut, is expected to perform better alongside Osa Odighizuwa this week. A strong showing could increase his trade value, particularly in discussions involving Vita Vea.
Gracen Halton made a notable impact in his NFL debut, but he played behind Sebastian Valdez. The 49ers may look to integrate him with the starters or give him earlier playing time to assess his capabilities against stronger opponents. A successful performance could earn him a rotational role for the upcoming season.
With Mykel Williams on the PUP list and Nick Bosa unlikely to participate in the preseason, Sam Okuayinonu stands as the primary rusher available to play alongside the starters. This game provides him with a crucial opportunity to secure a starting position for Week 1.
Jaden Dugger has been versatile in the 49ers' defense, and his role as the third linebacker remains uncertain with Fred Warner and Dre Greenlaw starting. His performance will be pivotal in determining his position within the lineup.
Renardo Green has held onto his starting role despite offseason challenges, successfully fending off competition from Jack Jones and Nate Hobbs. His adaptation to the new defensive scheme under Morris will be closely evaluated.
