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Purdy's Four Touchdowns Carry Short-Handed 49ers Past Cardinals 36-30, to 3-0

A first-quarter hook-and-ladder set the tone, and George Kittle's second touchdown with 1:31 left held off Arizona as injuries piled up for San Francisco.

Knox Esparza

September 28, 20262 min read

Sunlit football field - illustration, Jake Team LLC

Even with its receiving corps thinning by the quarter, San Francisco found a way. Brock Purdy threw four touchdown passes and the 49ers held off the Arizona Cardinals 36-30 Sunday at Levi's Stadium to stay unbeaten at 3-0.

A trick play to start

The first touchdown came on a call Kyle Shanahan made on the third play from scrimmage. Facing third-and-12, Purdy threw a quick pass to Mike Evans, who flipped the ball back to Deebo Samuel as he was tackled, and Samuel ran the rest of the way for an 82-yard score, the Associated Press reported.

Evans caught a 23-yard touchdown pass early in the second quarter for a 14-0 lead. Arizona answered with two Chad Ryland field goals, and Eddy Pineiro's 57-yard field goal at the end of the half made it 17-6.

Holding on

Christian McCaffrey's 1-yard run pushed the lead to 23-6 in the third quarter, but Arizona scored touchdowns on consecutive drives through Jacoby Brissett's passes to Michael Wilson and Jeremiyah Love to pull within 23-20. George Kittle's 10-yard touchdown catch made it 29-20, and after Brissett ran one in to make it 29-27, Purdy found Kittle again from 20 yards with 1:31 to play.

The injury list

The win came at a cost. Evans left in the first half with a rib injury, left tackle Trent Williams left with a stinger and linebacker Dre Greenlaw left with a quadriceps injury, according to the AP. San Francisco was already without receivers Ricky Pearsall, De'Zhaun Stribling and Demarcus Robinson.

Leaders

Purdy completed 15 of 27 passes for 297 yards and four touchdowns. Kittle caught six passes for 82 yards and two scores, McCaffrey ran for 75 yards and a touchdown, and linebacker Fred Warner made 17 tackles. Brissett completed 38 of 52 passes for 280 yards for Arizona, now 1-2.

Sources

ESPN box score, Cardinals at 49ers, Sept. 27, 2026

The Associated Press, "Purdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals" (Sept. 27, 2026)

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Knox Esparza

Knox Esparza covers Pleasanton high school and area college sports.

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